Title, Authors, Journal name: New Synthetic Route for the Enantioselective Total Synthesis of Salinosporamide A and Biologically Active Analogues. Reddy, Leleti Rajender; Fournier, Jean-Francois; Reddy, B. V. Subba; Corey, E. J.. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. Organic Letters (2005), 7(13), 2699-2701.

Abstract: A total synthesis of the salinosporamide analog I is described. A key step early in the synthesis was the Baylis-Hillman cyclization of II to the .gamma.-lactam III with 9:1 diastereoselectivity and in good yield. In addn., the .gamma.-lactam III has been transformed efficiently into .beta.-Me omuralide (IV).